3'-Bromopropiophenone; 3-Bromophenyl ethyl ketone; 3-Bromopropiophenone -Drug Synthesis Database

【结构式】

【分子编号】56972

【品名】3'-Bromopropiophenone; 3-Bromophenyl ethyl ketone; 3-Bromopropiophenone

【CA登记号】19829-31-3

【分子式】C₉H₉BrO

【分子量】213.07386

【元素组成】C 50.73% H 4.26% Br 37.5% O 7.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title thio semicarbazone is prepared by condensation of 3-bromopropiophenone (I) with thio semicarbazide (II) in MeOH in the presence of a catalytic amount of HOAc. (1,2)

参考文献中间体

合成目标

【1】 Du, X.; et al.; Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem 2002, 45, 13, 2695.
【2】 Du, X.; Cohen, F.E.; McKerrow, J.H.; Guo, C. (University of California, Oakland); Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use. US 2004014801 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	56972	3'-Bromopropiophenone; 3-Bromophenyl ethyl ketone; 3-Bromopropiophenone	19829-31-3	C₉H₉BrO	详情	详情
(II)	12954	1-Hydrazinecarbothioamide; Thiosemicarbazide	79-19-6	CH₅N₃S	详情	详情

Extended Information