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【结 构 式】 
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【药物名称】 【化学名称】1-(3-Bromophenyl)propan-1-one thiosemicarbazone 【CA登记号】 【 分 子 式 】C10H12BrN3S 【 分 子 量 】286.19524 |
【开发单位】Pfizer (Originator), University of California, Oakland (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antitrypanosomals, Treatment of Protozoal Diseases, Cysteine Protease Inhibitors |
合成路线1
The title thio semicarbazone is prepared by condensation of 3-bromopropiophenone (I) with thio semicarbazide (II) in MeOH in the presence of a catalytic amount of HOAc. (1,2)
| 【1】 Du, X.; et al.; Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem 2002, 45, 13, 2695. |
| 【2】 Du, X.; Cohen, F.E.; McKerrow, J.H.; Guo, C. (University of California, Oakland); Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use. US 2004014801 . |
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