trans-1-Nitro-2-phenylethylene -Drug Synthesis Database

【结构式】

【分子编号】56968

【品名】trans-1-Nitro-2-phenylethylene

【CA登记号】5153-67-3

【分子式】C₈H₇NO₂

【分子量】149.14912

【元素组成】C 64.42% H 4.73% N 9.39% O 21.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Condensation of naltrexone (I) with benzylamine produces the intermediate imine (II) which is subsequently cyclized with trans-beta-nitrostyrene (III) to produce the required pyrrolomorphinan.

参考文献中间体

合成目标

【1】 Miller, C.N.; Traynor, J.R.; Aceto, M.D.; Husbands, S.M.; Lewis, J.W.; Srivastava, S.K.; 4'-Arylpyrrolomorphinans: Effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity. J Med Chem 2002, 45, 2, 537.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25079	(1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10-trien-14-one; Naltrexone	16590-41-3	C₂₀H₂₃NO₄	详情	详情
(II)	56967	(1S,5R,13R,17S)-14-(benzylimino)-4-(cyclopropylmethyl)-12-oxa-4-azapentacyclo[9.6.1.0~1,13~.0~5,17~.0~7,18~]octadeca-7(18),8,10-triene-10,17-diol		C₂₇H₃₀N₂O₃	详情	详情
(III)	56968	trans-1-Nitro-2-phenylethylene	5153-67-3	C₈H₇NO₂	详情	详情

Extended Information