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【结 构 式】 
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【药物名称】 【化学名称】1'-Benzyl-17-(cyclopropylmethyl)-6,7-didehydro-4,5alpha-epoxy-3,14beta-dihydroxy-4'-phenylpyrrolo[2',3':6,7]morphinan 【CA登记号】 【 分 子 式 】C35H34N2O3 【 分 子 量 】530.67283 |
【开发单位】University of Bath (Originator), University of Bristol (Originator), University of Michigan (Originator), University of Virginia (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Opioid Analgesics, delta-Opioid Antagonists |
合成路线1
Condensation of naltrexone (I) with benzylamine produces the intermediate imine (II) which is subsequently cyclized with trans-beta-nitrostyrene (III) to produce the required pyrrolomorphinan.
| 【1】 Miller, C.N.; Traynor, J.R.; Aceto, M.D.; Husbands, S.M.; Lewis, J.W.; Srivastava, S.K.; 4'-Arylpyrrolomorphinans: Effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity. J Med Chem 2002, 45, 2, 537. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25079 | (1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10-trien-14-one; Naltrexone | 16590-41-3 | C20H23NO4 | 详情 | 详情 |
| (II) | 56967 | (1S,5R,13R,17S)-14-(benzylimino)-4-(cyclopropylmethyl)-12-oxa-4-azapentacyclo[9.6.1.0~1,13~.0~5,17~.0~7,18~]octadeca-7(18),8,10-triene-10,17-diol | C27H30N2O3 | 详情 | 详情 | |
| (III) | 56968 | trans-1-Nitro-2-phenylethylene | 5153-67-3 | C8H7NO2 | 详情 | 详情 |
Extended Information