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【结 构 式】 
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【分子编号】56786 【品名】 【CA登记号】 |
【 分 子 式 】C48H72Br8O32 【 分 子 量 】1800.31248 【元素组成】C 32.02% H 4.03% Br 35.51% O 28.44% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IIb)Gamma-cyclodextrin (I) was converted to the halogen derivative (II) by treatment with iodine or bromine and triphenylphosphine. Nucleophilic displacement of the halogen atoms of (II) with the sodium salt of 3-mercaptopropionic acid furnished the title compound
| 【1】 Bom, A.; Bennet, D.J.; Adam, J.M.; et al.; Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: Synthesis and structure-activity relationships. J Med Chem 2002, 45, 9, 1806. |
| 【2】 Bennet, D.J.; Palin, R.; Zhang, M. (Akzo Nobel N.V.); 6-Mercapto-cyclodextrin derivs.: Reversal agents for drug-induced neuromuscular block. WO 0140316 . |
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