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【结 构 式】 
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【药物名称】Sugammadex Sodium, ORG-25969, Bridion 【化学名称】6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt 【CA登记号】343306-79-6, 343306-71-8 (free acid) 【 分 子 式 】C72H104Na8O48S8 【 分 子 量 】2178.03328 |
【开发单位】Akzo Nobel (Originator) 【药理作用】Specific Antidotes, TREATMENT OF POISONING, DRUG ABUSE & DEPENDENCY |
合成路线1
Gamma-cyclodextrin (I) was converted to the halogen derivative (II) by treatment with iodine or bromine and triphenylphosphine. Nucleophilic displacement of the halogen atoms of (II) with the sodium salt of 3-mercaptopropionic acid furnished the title compound
| 【1】 Bom, A.; Bennet, D.J.; Adam, J.M.; et al.; Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: Synthesis and structure-activity relationships. J Med Chem 2002, 45, 9, 1806. |
| 【2】 Bennet, D.J.; Palin, R.; Zhang, M. (Akzo Nobel N.V.); 6-Mercapto-cyclodextrin derivs.: Reversal agents for drug-induced neuromuscular block. WO 0140316 . |
Extended Information