4-(acetylamino)phenyl 4-bromobutanoate -Drug Synthesis Database

【结构式】

【分子编号】56709

【品名】4-(acetylamino)phenyl 4-bromobutanoate

【CA登记号】

【分子式】C₁₂H₁₄BrNO₃

【分子量】300.1521

【元素组成】C 48.02% H 4.7% Br 26.62% N 4.67% O 15.99%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The esterification of paracetamol (I) with 4-bromobutyric acid (II) by means of DCC and DMAP in DMF gives the corresponding ester (III), which is finally treated with AgNO3 in hot acetonitrile to yield the target nitrate ester.

参考文献中间体

合成目标

【1】 Del Soldato, P. (NicOx SA); Pharmaceutical cpds.. EP 1252133; WO 0112584 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	21611	4'-Hydroxyacetanilide;4-Acetamidophenol;N-Acetyl-4-aminophenol;Paracetamol;Acetaminophen;p-Hydroxyacetanilide; Paracetamol; N-(4-hydroxyphenyl)acetamide	103-90-2	C₈H₉NO₂	详情	详情
(II)	40604	4-bromobutyric acid	2623-87-2	C₄H₇BrO₂	详情	详情
(III)	56709	4-(acetylamino)phenyl 4-bromobutanoate		C₁₂H₁₄BrNO₃	详情	详情

Extended Information