|
【结 构 式】 
|
【药物名称】NO-Paracetamol, NCX-701, Nitroparacetamol 【化学名称】4-(Nitrooxy)butyric acid 4-acetamidophenyl ester 【CA登记号】 【 分 子 式 】C12H16N2O6 【 分 子 量 】284.27112 |
【开发单位】NicOx (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antipyretics, Neuropathic Pain, Treatment of, Non-Opioid Analgesics, Nitric Oxide Donors, Non-Steroidal Antiinflammatory Drugs |
合成路线1
The esterification of paracetamol (I) with 4-bromobutyric acid (II) by means of DCC and DMAP in DMF gives the corresponding ester (III), which is finally treated with AgNO3 in hot acetonitrile to yield the target nitrate ester.
| 【1】 Del Soldato, P. (NicOx SA); Pharmaceutical cpds.. EP 1252133; WO 0112584 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21611 | 4'-Hydroxyacetanilide;4-Acetamidophenol;N-Acetyl-4-aminophenol;Paracetamol;Acetaminophen;p-Hydroxyacetanilide; Paracetamol; N-(4-hydroxyphenyl)acetamide | 103-90-2 | C8H9NO2 | 详情 | 详情 |
| (II) | 40604 | 4-bromobutyric acid | 2623-87-2 | C4H7BrO2 | 详情 | 详情 |
| (III) | 56709 | 4-(acetylamino)phenyl 4-bromobutanoate | C12H14BrNO3 | 详情 | 详情 |
Extended Information