【结 构 式】 |
【分子编号】56586 【品名】10-fluoro-3-(2-fluorophenyl)-5-oxo-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]quinoline-8-carboxylic acid 【CA登记号】 |
【 分 子 式 】C25H15F2NO3 【 分 子 量 】415.3958464 【元素组成】C 72.29% H 3.64% F 9.15% N 3.37% O 11.55% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XVIII)Aldehyde (XVII) was further oxidized to carboxylic acid (XVIII) using sodium chlorite. Conversion of acid (XVIII) into the methyl ester (XIX) was effected by treatment with iodomethane and K2CO3. Finally, the two-step reduction of the carbonyl group of (XIX) with NaBH4 followed by HI/Ac2O, proceeded with concomitant ester hydrolysis, yielding the title compound.
【1】 Chujo, I.; et al.; Synthetic study on novel immunosuppressant KF20444. Bioorg Med Chem 2001, 9, 12, 3273. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XVII) | 56585 | 10-fluoro-3-(2-fluorophenyl)-5-oxo-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]quinoline-8-carbaldehyde | C25H15F2NO2 | 详情 | 详情 | |
(XVIII) | 56586 | 10-fluoro-3-(2-fluorophenyl)-5-oxo-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]quinoline-8-carboxylic acid | C25H15F2NO3 | 详情 | 详情 | |
(XIX) | 56587 | methyl 10-fluoro-3-(2-fluorophenyl)-5-oxo-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-b]quinoline-8-carboxylate | C26H17F2NO3 | 详情 | 详情 |
Extended Information