2-(4-morpholinyl)ethyl 2-chloronicotinate -Drug Synthesis Database

【结构式】

【分子编号】56318

【品名】2-(4-morpholinyl)ethyl 2-chloronicotinate

【CA登记号】

【分子式】C₁₂H₁₅ClN₂O₃

【分子量】270.71548

【元素组成】C 53.24% H 5.58% Cl 13.1% N 10.35% O 17.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

In a different procedure, 2-chloronicotinic acid (III) was chlorinated to (IV) by means of boiling thionyl chloride. Condensation of acid chloride (IV) with 2-morpholinoethanol (V) gave rise to the morpholinoethyl chloronicotinate (VI). Finally, displacement of the 2-chloro with m-(trifluoromethyl)aniline (VII) in the presence of zinc oxide and iodine furnished the title compound.

参考文献中间体

合成目标

【1】 Chiesi, P.; Servadio, V.; Pighi, R. (Chiesi Farmaceutici SpA); Processes for the preparation of morniflumate and analogous cpds.. EP 0349902 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	28824	2-Chloropyridine-3-carboxylic acid; 2-Chloronicotinic acid	2942-59-8	C₆H₄ClNO₂	详情	详情
(IV)	15224	2-chloronicotinoyl chloride	49609-84-9	C₆H₃Cl₂NO	详情	详情
(V)	12856	4-(2-Hydroxyethyl)morpholine; 2-(4-Morpholinyl)-1-ethanol; N-(2-Hydroxyethyl)morpholine	622-40-2	C₆H₁₃NO₂	详情	详情
(VI)	56318	2-(4-morpholinyl)ethyl 2-chloronicotinate		C₁₂H₁₅ClN₂O₃	详情	详情
(VII)	26347	3-(trifluoromethyl)phenylamine; 3-(trifluoromethyl)aniline; 3-aminobenzotrifluoride	98-16-8	C₇H₆F₃N	详情	详情

Extended Information