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【结 构 式】 
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【分子编号】56168 【品名】2-methyl-1-[4-(trifluoromethyl)phenyl]-1-propanone 【CA登记号】 |
【 分 子 式 】C11H11F3O 【 分 子 量 】216.2029496 【元素组成】C 61.11% H 5.13% F 26.36% O 7.4% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)In a different approach, addition of isopropylmagnesium bromide to 4-(trifluoromethyl)benzaldehyde (V) afforded alcohol (VI), which was further oxidized to the corresponding ketone (VII) by treatment with pyridinium chlorochromate. Bromination of 4'-(trifluoromethyl)isobutyrophenone (VII) in HOAc provided bromo ketone (VIII). Sulfide (IV) was then obtained by displacement of the bromide group of (VIII) with sodium methanethiolate.
| 【1】 Tokizawa, M.; Kanamaru, Y.; Matsumoto, M.; Asaoka, T.; Matsuda, H.; Kuraishi, T.; Maebashi, K.; Taido, N.; Kawahara, R. (SSP Co., Ltd.); Triazole derivs.. EP 0435081; JP 1991223266; US 5147886 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 56166 | 2-methyl-2-(methylsulfanyl)-1-[4-(trifluoromethyl)phenyl]-1-propanone | C12H13F3OS | 详情 | 详情 | |
| (V) | 13380 | 4-(Trifluoromethyl)benzaldehyde; alpha,alpha,alpha-Trifluoro-p-tolualdehyde | 455-19-6 | C8H5F3O | 详情 | 详情 |
| (VI) | 56167 | 2-methyl-1-[4-(trifluoromethyl)phenyl]-1-propanol | C11H13F3O | 详情 | 详情 | |
| (VII) | 56168 | 2-methyl-1-[4-(trifluoromethyl)phenyl]-1-propanone | C11H11F3O | 详情 | 详情 | |
| (VIII) | 56169 | 2-bromo-2-methyl-1-[4-(trifluoromethyl)phenyl]-1-propanone | C11H10BrF3O | 详情 | 详情 |
Extended Information