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【结 构 式】 
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【分子编号】56029 【品名】1-chloro-2-[(3-methyl-2-butenyl)oxy]-4-nitrobenzene; 2-chloro-5-nitrophenyl 3-methyl-2-butenyl ether 【CA登记号】 |
【 分 子 式 】C11H12ClNO3 【 分 子 量 】241.67392 【元素组成】C 54.67% H 5% Cl 14.67% N 5.8% O 19.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The diazonium salt prepared from 2-amino-5-nitrophenol (I) was subjected to Sandmeyer reaction in the presence of HCl and CuCl to afford the chlorophenol derivative (II). Subsequent alkylation of phenol (II) with prenyl bromide (III) produced ether (IV). Amine (V) was then obtained by reduction of the nitro group of (IV) employing iron powder in the presence of HCl.
| 【1】 Brouwer, W.G.; Osika, E.M.; Pierce, B.J. (Uniroyal Chemical Company, Inc.); Furan- and thiophenecarbothioamide derivs., their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants. EP 0874839; JP 1999504657; US 5696151; WO 9719940 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 33067 | 2-amino-5-nitrophenol | 121-88-0 | C6H6N2O3 | 详情 | 详情 |
| (II) | 56028 | 2-chloro-5-nitrophenol | 619-10-3 | C6H4ClNO3 | 详情 | 详情 |
| (III) | 12989 | 4-Bromo-2-methyl-2-butene; 1-Bromo-3-methyl-2-butene | 870-63-3 | C5H9Br | 详情 | 详情 |
| (IV) | 56029 | 1-chloro-2-[(3-methyl-2-butenyl)oxy]-4-nitrobenzene; 2-chloro-5-nitrophenyl 3-methyl-2-butenyl ether | C11H12ClNO3 | 详情 | 详情 | |
| (V) | 56030 | 4-chloro-3-[(3-methyl-2-butenyl)oxy]phenylamine; 4-chloro-3-[(3-methyl-2-butenyl)oxy]aniline | C11H14ClNO | 详情 | 详情 |
Extended Information