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【结 构 式】 
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【分子编号】55812 【品名】4-(carboxymethyl)benzenediazonium chloride 【CA登记号】 |
【 分 子 式 】C8H7ClN2O2 【 分 子 量 】198.60856 【元素组成】C 48.38% H 3.55% Cl 17.85% N 14.1% O 16.11% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The diazotization of 2-(4-aminophenyl)acetic acid (I) by means of NaNO2 and HCl gives the diazonium salt (II), which is then condensed with 2-hydroxybenzoic acid (III) to provide the target azocompound.
| 【1】 Riggs-Sauthier, J.A.; Malson, E.; Harris, M.; Myung, S.; Liddle, R.; Ekwuribe, N.; Synthesis and activity of novel 5-aminosalicylic acid (5-ASA)-containing prodrugs for the treatment of inflammatory bowel disease. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 305. |
| 【2】 Ekwuribe, N.N.; Riggs-Sauthier, J. (Nobex Corp.); Immunoregulatory cpds. and derivs. and methods of treating diseases therewith. WO 0218324 . |
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