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【结 构 式】 
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【药物名称】NOBEX-AA-004, NAA-004, APAZA 【化学名称】5-[4-(Carboxymethyl)phenyldiazenyl]-2-hydroxybenzoic acid 【CA登记号】 【 分 子 式 】C15H12N2O5 【 分 子 量 】300.27329 |
【开发单位】Nobex (Originator) 【药理作用】Chemical Delivery Systems, DRUG DELIVERY, Drug Delivery Systems, GASTROINTESTINAL DRUGS, IMMUNOMODULATING AGENTS, Immunomodulators, Inflammatory Bowel Disease, Agents for |
合成路线1
The diazotization of 2-(4-aminophenyl)acetic acid (I) by means of NaNO2 and HCl gives the diazonium salt (II), which is then condensed with 2-hydroxybenzoic acid (III) to provide the target azocompound.
| 【1】 Riggs-Sauthier, J.A.; Malson, E.; Harris, M.; Myung, S.; Liddle, R.; Ekwuribe, N.; Synthesis and activity of novel 5-aminosalicylic acid (5-ASA)-containing prodrugs for the treatment of inflammatory bowel disease. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 305. |
| 【2】 Ekwuribe, N.N.; Riggs-Sauthier, J. (Nobex Corp.); Immunoregulatory cpds. and derivs. and methods of treating diseases therewith. WO 0218324 . |
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