tert-butyl (1R)-2-(dimethylamino)-1-methylethylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】55657

【品名】tert-butyl (1R)-2-(dimethylamino)-1-methylethylcarbamate

【CA登记号】

【分子式】C₁₀H₂₂N₂O₂

【分子量】202.29696

【元素组成】C 59.37% H 10.96% N 13.85% O 15.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

The intermediate chiral diamine (IV) (see Scheme no. 28794701a, intermediate (V)) is prepared as follows: Reduction of N-Boc-D-alanine methyl ester (I) with DIBAL affords N-Boc-alaninal (II), which is reductively aminated with dimethylamine in the presence of NaBH3CN to afford the Boc-protected diamine (III). The N-Boc group of (III) is finally removed under acidic conditions to provide the target (R)-diamine (IV).

参考文献中间体

合成目标

【1】 Vicker, N.; Burgess, L.; Chuckowree, I.S.; et al.; Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents. J Med Chem 2002, 45, 3, 721.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(V)	47916	(2R)-N(1),N(1)-dimethyl-1,2-propanediamine; N-[(2R)-2-aminopropyl]-N,N-dimethylamine	C₅H₁₄N₂	详情	详情
(VI)	55655	methyl (2R)-2-[(tert-butoxycarbonyl)amino]propanoate	C₉H₁₇NO₄	详情	详情
(VII)	55656	tert-butyl (1R)-1-methyl-2-oxoethylcarbamate	C₈H₁₅NO₃	详情	详情
(VIII)	55657	tert-butyl (1R)-2-(dimethylamino)-1-methylethylcarbamate	C₁₀H₂₂N₂O₂	详情	详情

Extended Information