【结 构 式】 |
【分子编号】55656 【品名】tert-butyl (1R)-1-methyl-2-oxoethylcarbamate 【CA登记号】 |
【 分 子 式 】C8H15NO3 【 分 子 量 】173.21204 【元素组成】C 55.47% H 8.73% N 8.09% O 27.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VII)The intermediate chiral diamine (IV) (see Scheme no. 28794701a, intermediate (V)) is prepared as follows: Reduction of N-Boc-D-alanine methyl ester (I) with DIBAL affords N-Boc-alaninal (II), which is reductively aminated with dimethylamine in the presence of NaBH3CN to afford the Boc-protected diamine (III). The N-Boc group of (III) is finally removed under acidic conditions to provide the target (R)-diamine (IV).
【1】 Vicker, N.; Burgess, L.; Chuckowree, I.S.; et al.; Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents. J Med Chem 2002, 45, 3, 721. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(V) | 47916 | (2R)-N(1),N(1)-dimethyl-1,2-propanediamine; N-[(2R)-2-aminopropyl]-N,N-dimethylamine | C5H14N2 | 详情 | 详情 | |
(VI) | 55655 | methyl (2R)-2-[(tert-butoxycarbonyl)amino]propanoate | C9H17NO4 | 详情 | 详情 | |
(VII) | 55656 | tert-butyl (1R)-1-methyl-2-oxoethylcarbamate | C8H15NO3 | 详情 | 详情 | |
(VIII) | 55657 | tert-butyl (1R)-2-(dimethylamino)-1-methylethylcarbamate | C10H22N2O2 | 详情 | 详情 |
Extended Information