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【结 构 式】

【分子编号】55656

【品名】tert-butyl (1R)-1-methyl-2-oxoethylcarbamate

【CA登记号】

【 分 子 式 】C8H15NO3

【 分 子 量 】173.21204

【元素组成】C 55.47% H 8.73% N 8.09% O 27.71%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

The intermediate chiral diamine (IV) (see Scheme no. 28794701a, intermediate (V)) is prepared as follows: Reduction of N-Boc-D-alanine methyl ester (I) with DIBAL affords N-Boc-alaninal (II), which is reductively aminated with dimethylamine in the presence of NaBH3CN to afford the Boc-protected diamine (III). The N-Boc group of (III) is finally removed under acidic conditions to provide the target (R)-diamine (IV).

1 Vicker, N.; Burgess, L.; Chuckowree, I.S.; et al.; Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents. J Med Chem 2002, 45, 3, 721.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(V) 47916 (2R)-N(1),N(1)-dimethyl-1,2-propanediamine; N-[(2R)-2-aminopropyl]-N,N-dimethylamine C5H14N2 详情 详情
(VI) 55655 methyl (2R)-2-[(tert-butoxycarbonyl)amino]propanoate C9H17NO4 详情 详情
(VII) 55656 tert-butyl (1R)-1-methyl-2-oxoethylcarbamate C8H15NO3 详情 详情
(VIII) 55657 tert-butyl (1R)-2-(dimethylamino)-1-methylethylcarbamate C10H22N2O2 详情 详情
Extended Information