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【结 构 式】 
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【分子编号】55595 【品名】4-[4-(benzyloxy)phenyl]butanal 【CA登记号】 |
【 分 子 式 】C17H18O2 【 分 子 量 】254.32872 【元素组成】C 80.28% H 7.13% O 12.58% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Demethylation of 4-(4-methoxyphenyl)butanol (I) by means of BBr3 gave phenol (II), which was subsequently protected as the benzyl ether (III) with benzyl bromide and K2CO3. Oxidation of the primary alcohol (III) employing pyridinium chlorochromate yielded aldehyde (IV). Finally, reductive amination of aldehyde (IV) with norepinephrine (V), with concomitant O-debenzylation, was accomplished by hydrogenation in the presence of both PtO2 and Pd/C.
| 【1】 Tuttle, R.R.; Browne III, C.E. (Sicor Inc.); Diagnosis, evaluation & treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist. EP 0329464; JP 1998276991; US 5108363 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 55592 | 4-(4-methoxyphenyl)-1-butanol | C11H16O2 | 详情 | 详情 | |
| (II) | 55593 | 4-(4-hydroxybutyl)phenol | C10H14O2 | 详情 | 详情 | |
| (III) | 55594 | 4-[4-(benzyloxy)phenyl]-1-butanol | C17H20O2 | 详情 | 详情 | |
| (IV) | 55595 | 4-[4-(benzyloxy)phenyl]butanal | C17H18O2 | 详情 | 详情 | |
| (V) | 55596 | (-)-Arterenol; 3,4-Dihydroxyphenylethanolamine; L-Arterenol; L-Norepinephrine; L-Noradrenaline; Norepinephrine | 51-41-2 | C8H11NO3 | 详情 | 详情 |
Extended Information