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【结 构 式】

【分子编号】55388

【品名】2-bromo-1-(3-methylphenyl)-2-[4-(methylsulfonyl)phenyl]-1-ethanone

【CA登记号】

【 分 子 式 】C16H15BrO3S

【 分 子 量 】367.2633

【元素组成】C 52.33% H 4.12% Br 21.76% O 13.07% S 8.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The Friedel-Crafts condensation of 2-[4-(methylsulfanyl)phenyl]acetyl chloride (I) with toluene (II) gives 1-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]ethanone (III), which is oxidized with MCPBA to yield the corresponding sulfonyl compound (IV). The bromination of (IV) with Br2 affords the bromoethanone (V), which is finally cyclized with pyridine-2-amine (VI) to provide the target imidazopyridine compound.

1 Farrerons, C.; et al.; Diarylimidazo[1,2-a]pyridine derivatives as a new class of selective COX-2 inhibitors. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P2.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 25755 2-[4-(methylsulfanyl)phenyl]acetyl chloride C9H9ClOS 详情 详情
(II) 12890 Toluene 108-88-3 C7H8 详情 详情
(III) 55386 1-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1-ethanone C16H16OS 详情 详情
(IV) 55387 1-(3-methylphenyl)-2-[4-(methylsulfonyl)phenyl]-1-ethanone C16H16O3S 详情 详情
(V) 55388 2-bromo-1-(3-methylphenyl)-2-[4-(methylsulfonyl)phenyl]-1-ethanone C16H15BrO3S 详情 详情
(VI) 11305 2-Pyridinamine; 2-Pyridinylamine; 2-Aminopyridine 504-29-0 C5H6N2 详情 详情
Extended Information