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【结 构 式】 
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【药物名称】 【化学名称】2-(3-Methylphenyl)-3-[4-(methylsulfonyl)phenyl]imidazo[1,2-a]pyridine 【CA登记号】 【 分 子 式 】C21H18N2O2S 【 分 子 量 】362.45381 |
【开发单位】Salvat (Originator) 【药理作用】Antiarthritic Drugs, TREATMENT OF MUSCULOSKELETAL & CONNECTIVE TISSUE DISEASES, Cyclooxygenase-2 Inhibitors |
合成路线1
The Friedel-Crafts condensation of 2-[4-(methylsulfanyl)phenyl]acetyl chloride (I) with toluene (II) gives 1-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]ethanone (III), which is oxidized with MCPBA to yield the corresponding sulfonyl compound (IV). The bromination of (IV) with Br2 affords the bromoethanone (V), which is finally cyclized with pyridine-2-amine (VI) to provide the target imidazopyridine compound.
| 【1】 Farrerons, C.; et al.; Diarylimidazo[1,2-a]pyridine derivatives as a new class of selective COX-2 inhibitors. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P2. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25755 | 2-[4-(methylsulfanyl)phenyl]acetyl chloride | C9H9ClOS | 详情 | 详情 | |
| (II) | 12890 | Toluene | 108-88-3 | C7H8 | 详情 | 详情 |
| (III) | 55386 | 1-(3-methylphenyl)-2-[4-(methylsulfanyl)phenyl]-1-ethanone | C16H16OS | 详情 | 详情 | |
| (IV) | 55387 | 1-(3-methylphenyl)-2-[4-(methylsulfonyl)phenyl]-1-ethanone | C16H16O3S | 详情 | 详情 | |
| (V) | 55388 | 2-bromo-1-(3-methylphenyl)-2-[4-(methylsulfonyl)phenyl]-1-ethanone | C16H15BrO3S | 详情 | 详情 | |
| (VI) | 11305 | 2-Pyridinamine; 2-Pyridinylamine; 2-Aminopyridine | 504-29-0 | C5H6N2 | 详情 | 详情 |
Extended Information