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【结 构 式】

【分子编号】55347

【品名】benzoic acid

【CA登记号】

【 分 子 式 】C7H6O2

【 分 子 量 】122.12344

【元素组成】C 68.85% H 4.95% O 26.2%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The Grignard reaction of phenylmagnesium bromide (I) with 11C labeled CO2 (II) in THF gives the radiolabeled benzoic acid (III), which is treated with phthaloyl dichloride (IV) in the same solvent to yield radiolabeled benzoyl chloride (V). Finally, this compound is treated with N-debenzoylated paclitaxel (VI) in acetonitrile to afford the target radiolabeled paclitaxel.

1 Ravert, H.T.; et al.; Radiosynthesis of [11C]paclitaxel. J Label Compd Radiopharm 2002, 45, 6, 471.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 17616 bromo(phenyl)magnesium; Phenyl Magnesium Bromide 100-58-3 C6H5BrMg 详情 详情
(III) 10202 Benzoic acid 65-85-0 C7H6O2 详情 详情
(III) 55347 benzoic acid C7H6O2 详情 详情
(IV) 23811 phthaloyl dichloride;1,2-Benzenedicarbonyl dichloride;o-Phthaloyl chloride 88-95-9 C8H4Cl2O2 详情 详情
(V) 10463 Benzoyl chloride 98-88-4 C7H5ClO 详情 详情
(V) 55348 benzoyl chloride C7H5ClO 详情 详情
(VI) 10729 (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetoxy)-15-[[(2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl]oxy]-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate C40H47NO13 详情 详情
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