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【结 构 式】 
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【分子编号】55156 【品名】 【CA登记号】 |
【 分 子 式 】C76H109CoN19O17P 【 分 子 量 】1650.726282 【元素组成】C 55.3% H 6.66% Co 3.57% N 16.12% O 16.48% P 1.88% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Adenosylcobalamin-b-monocarboxylic acid (I) was coupled to 1,4-butanediamine (II) in the presence of EDC and HOBt to afford the N-(4-aminobutyl)amide (III). Subsequent acylation of amino amide (III) by diethylenetriaminopentaacetic dianhydride (IV) gave rise to the title compound.
| 【1】 Hogenkamp, H.P.C.; Collins, D.A.; Transcobalamin II receptor imaging via radiolabeled diethylene-triaminepentaacetate cobalamin analogs. J Nucl Med 1997, 38, 5, 717. |
| 【2】 Collins, D.A.; Hogenkamp, H.P.C. (Mayo Foundation for Medical Education and Research; University of Minnesota); Radionuclide labeling of vitamin B12 and coenzymes thereof. WO 9718231 . |
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