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【结 构 式】

【分子编号】55156

【品名】 

【CA登记号】

【 分 子 式 】C76H109CoN19O17P

【 分 子 量 】1650.726282

【元素组成】C 55.3% H 6.66% Co 3.57% N 16.12% O 16.48% P 1.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Adenosylcobalamin-b-monocarboxylic acid (I) was coupled to 1,4-butanediamine (II) in the presence of EDC and HOBt to afford the N-(4-aminobutyl)amide (III). Subsequent acylation of amino amide (III) by diethylenetriaminopentaacetic dianhydride (IV) gave rise to the title compound.

1 Hogenkamp, H.P.C.; Collins, D.A.; Transcobalamin II receptor imaging via radiolabeled diethylene-triaminepentaacetate cobalamin analogs. J Nucl Med 1997, 38, 5, 717.
2 Collins, D.A.; Hogenkamp, H.P.C. (Mayo Foundation for Medical Education and Research; University of Minnesota); Radionuclide labeling of vitamin B12 and coenzymes thereof. WO 9718231 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 55155   C72H99CoN17O18P 详情 详情
(II) 42070 1,4-butanediamine; 4-aminobutylamine 110-60-1 C4H12N2 详情 详情
(III) 55156   C76H109CoN19O17P 详情 详情
(IV) 49150 Diethylenetriaminepentaacetic acid; N,N-Bis[2-(2,6-dioxomorpholino)ethyl]glycine 23911-26-4 C14H19N3O8 详情 详情
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