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【结 构 式】 
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【药物名称】DTPA-adenosylcobalamin, DAC 【化学名称】N(b)-[4-[2-[N,N-Bis[2-[N,N-bis(carboxymethyl)amino]ethyl]amino]acetamido]butyl]-Co-(5'-deoxyadenosin-5'-yl)cobinamide f-(dihydrogen phosphate) inner salt 3'-ester with [5,6-dimethyl-1-(alpha-D-ribofuranosyl)benzimidazole-kappa-N3] 【CA登记号】191029-50-2 【 分 子 式 】C90H130CoN22O26P 【 分 子 量 】2026.0784 |
【开发单位】Mayo Foundation (Originator), University of Minnesota (Originator), Copharos (Licensee) 【药理作用】Diagnostic Agents, Diagnostic for Cancer, Radiopharmaceuticals |
合成路线1
Adenosylcobalamin-b-monocarboxylic acid (I) was coupled to 1,4-butanediamine (II) in the presence of EDC and HOBt to afford the N-(4-aminobutyl)amide (III). Subsequent acylation of amino amide (III) by diethylenetriaminopentaacetic dianhydride (IV) gave rise to the title compound.
| 【1】 Hogenkamp, H.P.C.; Collins, D.A.; Transcobalamin II receptor imaging via radiolabeled diethylene-triaminepentaacetate cobalamin analogs. J Nucl Med 1997, 38, 5, 717. |
| 【2】 Collins, D.A.; Hogenkamp, H.P.C. (Mayo Foundation for Medical Education and Research; University of Minnesota); Radionuclide labeling of vitamin B12 and coenzymes thereof. WO 9718231 . |