【结 构 式】 |
【分子编号】55094 【品名】(2S)-3-{4-[2-(9H-carbazol-9-yl)ethoxy]phenyl}-2-ethoxypropanoic acid 【CA登记号】 |
【 分 子 式 】C25H25NO4 【 分 子 量 】403.47784 【元素组成】C 74.42% H 6.25% N 3.47% O 15.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Condensation of 2-(carbazol-9-yl)ethanol (I) with (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)propionate (II) under Mitsunobu conditions using tributylphosphine and 1,1'-(azodicarbonyl)dipiperidine gave ether (III). Basic hydrolysis of the ethyl ester group of (III) provided carboxylic acid (IV), which was finally isolated as the corresponding arginine salt.
【1】 Sauerberg, P.; Pettersson, I.; Jeppesen, L.; et al.; Novel tricyclic-alpha-alkyloxyphenylpropionic acids: Dual PPAR/gamma alpha agonists with hypolipidemic and antidiabetic activity. J Med Chem 2002, 45, 4, 789. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 55092 | 2-(9H-carbazol-9-yl)-1-ethanol | C14H13NO | 详情 | 详情 | |
(II) | 50418 | ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate | C13H18O4 | 详情 | 详情 | |
(III) | 55093 | ethyl (2S)-3-{4-[2-(9H-carbazol-9-yl)ethoxy]phenyl}-2-ethoxypropanoate | C27H29NO4 | 详情 | 详情 | |
(IV) | 55094 | (2S)-3-{4-[2-(9H-carbazol-9-yl)ethoxy]phenyl}-2-ethoxypropanoic acid | C25H25NO4 | 详情 | 详情 |
Extended Information