2-(9H-carbazol-9-yl)-1-ethanol -Drug Synthesis Database

【结构式】

【分子编号】55092

【品名】2-(9H-carbazol-9-yl)-1-ethanol

【CA登记号】

【分子式】C₁₄H₁₃NO

【分子量】211.26336

【元素组成】C 79.59% H 6.2% N 6.63% O 7.57%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Condensation of 2-(carbazol-9-yl)ethanol (I) with (S)-ethyl 2-ethoxy-3-(4-hydroxyphenyl)propionate (II) under Mitsunobu conditions using tributylphosphine and 1,1'-(azodicarbonyl)dipiperidine gave ether (III). Basic hydrolysis of the ethyl ester group of (III) provided carboxylic acid (IV), which was finally isolated as the corresponding arginine salt.

参考文献中间体

合成目标

【1】 Sauerberg, P.; Pettersson, I.; Jeppesen, L.; et al.; Novel tricyclic-alpha-alkyloxyphenylpropionic acids: Dual PPAR/gamma alpha agonists with hypolipidemic and antidiabetic activity. J Med Chem 2002, 45, 4, 789.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	55092	2-(9H-carbazol-9-yl)-1-ethanol	C₁₄H₁₃NO	详情	详情
(II)	50418	ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate	C₁₃H₁₈O₄	详情	详情
(III)	55093	ethyl (2S)-3-{4-[2-(9H-carbazol-9-yl)ethoxy]phenyl}-2-ethoxypropanoate	C₂₇H₂₉NO₄	详情	详情
(IV)	55094	(2S)-3-{4-[2-(9H-carbazol-9-yl)ethoxy]phenyl}-2-ethoxypropanoic acid	C₂₅H₂₅NO₄	详情	详情

Extended Information