2,4-dichloro-5,6-dimethylpyrimidine -Drug Synthesis Database

【结构式】

【分子编号】54975

【品名】2,4-dichloro-5,6-dimethylpyrimidine

【CA登记号】

【分子式】C₆H₆Cl₂N₂

【分子量】177.03252

【元素组成】C 40.71% H 3.42% Cl 40.05% N 15.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IX)

Chlorination of 5,6-dimethyl-2,4-dihydroxypyrimidine (VIII) using phosphorus oxychloride in the presence of N,N-dimethylaniline provided dichloropyrimidine (IX). The 4-chloro group of (IX) was then selectively displaced with tetrahydroisoquinoline (IV) to afford adduct (X). The title compound was then obtained by condensation of the 2-chloropyrimidine (X) with 4-fluoroaniline (XI), followed by conversion to the corresponding hydrochloride salt

参考文献中间体

合成目标

【1】 Lee, J.W.; Chae, J.S.; Kim, C.S.; Kim, J.K.; Lim, D.S.; Shon, M.K.; Choi, Y.S.; Lee, S.H. (Yuhan Corp.); Novel pyrimidine derivs. and processes for the preparation thereof. EP 0775120; JP 1997509188; US 5750531; WO 9605177 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IV)	54971	1-methyl-1,2,3,4-tetrahydroisoquinoline		C₁₀H₁₃N	详情	详情
(VIII)	54974	2,4-Dihydroxy-5,6-dimethylpyrimidine; 5,6-Dimethyl-2,4-pyrimidinediol; 5,6-Dimethyluracil	26305-13-5	C₆H₈N₂O₂	详情	详情
(IX)	54975	2,4-dichloro-5,6-dimethylpyrimidine		C₆H₆Cl₂N₂	详情	详情
(X)	54976	2-(2-chloro-5,6-dimethyl-4-pyrimidinyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline		C₁₆H₁₈ClN₃	详情	详情
(XI)	37690	4-fluorophenylamine; 4-fluoroaniline	371-40-4	C₆H₆FN	详情	详情

Extended Information