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【结 构 式】 
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【分子编号】54974 【品名】2,4-Dihydroxy-5,6-dimethylpyrimidine; 5,6-Dimethyl-2,4-pyrimidinediol; 5,6-Dimethyluracil 【CA登记号】26305-13-5 |
【 分 子 式 】C6H8N2O2 【 分 子 量 】140.1418 【元素组成】C 51.42% H 5.75% N 19.99% O 22.83% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)Chlorination of 5,6-dimethyl-2,4-dihydroxypyrimidine (VIII) using phosphorus oxychloride in the presence of N,N-dimethylaniline provided dichloropyrimidine (IX). The 4-chloro group of (IX) was then selectively displaced with tetrahydroisoquinoline (IV) to afford adduct (X). The title compound was then obtained by condensation of the 2-chloropyrimidine (X) with 4-fluoroaniline (XI), followed by conversion to the corresponding hydrochloride salt
| 【1】 Lee, J.W.; Chae, J.S.; Kim, C.S.; Kim, J.K.; Lim, D.S.; Shon, M.K.; Choi, Y.S.; Lee, S.H. (Yuhan Corp.); Novel pyrimidine derivs. and processes for the preparation thereof. EP 0775120; JP 1997509188; US 5750531; WO 9605177 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 54971 | 1-methyl-1,2,3,4-tetrahydroisoquinoline | C10H13N | 详情 | 详情 | |
| (VIII) | 54974 | 2,4-Dihydroxy-5,6-dimethylpyrimidine; 5,6-Dimethyl-2,4-pyrimidinediol; 5,6-Dimethyluracil | 26305-13-5 | C6H8N2O2 | 详情 | 详情 |
| (IX) | 54975 | 2,4-dichloro-5,6-dimethylpyrimidine | C6H6Cl2N2 | 详情 | 详情 | |
| (X) | 54976 | 2-(2-chloro-5,6-dimethyl-4-pyrimidinyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline | C16H18ClN3 | 详情 | 详情 | |
| (XI) | 37690 | 4-fluorophenylamine; 4-fluoroaniline | 371-40-4 | C6H6FN | 详情 | 详情 |
Extended Information