(1aS,7bS)-2,2-dimethyl-N-phenyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromene-6-sulfonamide -Drug Synthesis Database

【结构式】

【分子编号】54663

【品名】(1aS,7bS)-2,2-dimethyl-N-phenyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromene-6-sulfonamide

【CA登记号】

【分子式】C₁₇H₁₇NO₄S

【分子量】331.39232

【元素组成】C 61.61% H 5.17% N 4.23% O 19.31% S 9.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

Asymmetric epoxidation of benzopyran (IV) using NaOCl in the presence of the chiral catalyst (S,S)-(+)-N,N'-bis(3,5-di-t-butylsalicylidene)-1,2-cyclohexanediaminomanganese (III) chloride produced the desired (S,S)-epoxide (X). The title compound was then obtained by oxirane ring opening in (X) with the lithium derivative of 2-piperidinone (XI) in hot THF.

参考文献中间体

合成目标

【1】 Manley, P.W. (Novartis AG; Novartis Deutschland GmbH); Benzopyrans and pharmaceutical compsns. containing them. EP 0828733; JP 1999505820; US 5905156; WO 9637490 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IV)	54658	2,2-dimethyl-N-phenyl-2H-chromene-6-sulfonamide		C₁₇H₁₇NO₃S	详情	详情
(X)	54663	(1aS,7bS)-2,2-dimethyl-N-phenyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromene-6-sulfonamide		C₁₇H₁₇NO₄S	详情	详情
(XI)	43366	2-piperidinone	675-20-7	C₅H₉NO	详情	详情

Extended Information