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【结 构 式】 
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【分子编号】54451 【品名】5-[(2R)oxiranylmethyl]-10,11-dihydro-5H-dibenzo[b,f]azepine 【CA登记号】 |
【 分 子 式 】C17H17NO 【 分 子 量 】251.32812 【元素组成】C 81.24% H 6.82% N 5.57% O 6.37% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of dibenzazepine (I) with the chiral epichlorohydrin (II) by means of NaNH2 in refluxing benzene gives the adduct (III), which is finally treated with isopropylamine (IV) to yield the target isopropanol derivative.
| 【1】 Levy, O.; et al.; A new class of antiarrhythmic-defibrillatory agents. Bioorg Med Chem Lett 2001, 11, 22, 2921. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37265 | 4'-(hydroxymethyl)[1,1'-biphenyl]-2-carbonitrile | C14H11NO | 详情 | 详情 | |
| (II) | 38067 | (2R)-2-(Chloromethyl)oxirane; (R)-Epichlorohydrin | 51594-55-9 | C3H5ClO | 详情 | 详情 |
| (III) | 54451 | 5-[(2R)oxiranylmethyl]-10,11-dihydro-5H-dibenzo[b,f]azepine | C17H17NO | 详情 | 详情 | |
| (IV) | 23933 | 2-Propanamine; Isopropylamine | 75-31-0 | C3H9N | 详情 | 详情 |
Extended Information