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【结 构 式】 
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【药物名称】 【化学名称】(-)-1-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-3-(isopropylamino)propan-2(S)-ol hydrochloride 【CA登记号】 【 分 子 式 】C20H27ClN2O 【 分 子 量 】346.90399 |
【开发单位】Scripps Research Institute (Originator), Technion - Israel Institute Technol. (Originator), Tel Aviv University (Originator) 【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS |
合成路线1
The reaction of dibenzazepine (I) with the chiral epichlorohydrin (II) by means of NaNH2 in refluxing benzene gives the adduct (III), which is finally treated with isopropylamine (IV) to yield the target isopropanol derivative.
| 【1】 Levy, O.; et al.; A new class of antiarrhythmic-defibrillatory agents. Bioorg Med Chem Lett 2001, 11, 22, 2921. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37265 | 4'-(hydroxymethyl)[1,1'-biphenyl]-2-carbonitrile | C14H11NO | 详情 | 详情 | |
| (II) | 38067 | (2R)-2-(Chloromethyl)oxirane; (R)-Epichlorohydrin | 51594-55-9 | C3H5ClO | 详情 | 详情 |
| (III) | 54451 | 5-[(2R)oxiranylmethyl]-10,11-dihydro-5H-dibenzo[b,f]azepine | C17H17NO | 详情 | 详情 | |
| (IV) | 23933 | 2-Propanamine; Isopropylamine | 75-31-0 | C3H9N | 详情 | 详情 |
Extended Information