bis(3-ethoxy-3-oxopropyl)zinc -Drug Synthesis Database

【结构式】

【分子编号】59200

【品名】bis(3-ethoxy-3-oxopropyl)zinc

【CA登记号】

【分子式】C₁₀H₁₈O₄Zn

【分子量】267.64052

【元素组成】C 44.88% H 6.78% O 23.91% Zn 24.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(LXXIX)

The organozinc reagent (LXXIX) was prepared by treatment of [(1-ethoxycyclopropyl)oxy]trimethylsilane (LXXVIII) with ZnCl2. Palladium-catalyzed coupling of (LXXIX) to phthalimidoacetyl chloride (VIII) furnished ethyl phthalimodolevulinate (XLI), which was finally hydrolyzed as in precedent methods.

参考文献中间体

合成目标

【1】 Wang, J.; Scott, A.I.; An efficient synthesis of delta-aminolevulinic acid (ALA) and its isotopomers. Tetrahedron Lett 1997, 38, 5, 739.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VIII)	10278	2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride	6780-38-7	C₁₀H₆ClNO₃	详情	详情
(XLI)	59167	ethyl 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-oxopentanoate		C₁₅H₁₅NO₅	详情	详情
(LXXVIII)	52291	Cyclopropanone ethyl trimethylsilyl acetal; (1-Ethoxycyclopropoxy)trimethylsilane		C₈H₁₈O₂Si	详情	详情
(LXXIX)	59200	bis(3-ethoxy-3-oxopropyl)zinc		C₁₀H₁₈O₄Zn	详情	详情

Extended Information