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【结 构 式】 
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【分子编号】54420 【品名】(2S)-2-(3,4-dichlorophenyl)-3-{2-[(2S)-2-(3,4-dichlorophenyl)-4-oxo-1,3-thiazolidin-3-yl]ethyl}-1,3-thiazolidin-4-one 【CA登记号】 |
【 分 子 式 】C20H16Cl4N2O2S2 【 分 子 量 】522.30212 【元素组成】C 45.99% H 3.09% Cl 27.15% N 5.36% O 6.13% S 12.28% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：The cyclocondensation of N,N'-bis(3,4-dichlorobenzylidene)ethylenediamine (I) with 2-sulfanylacetic acid (II) in refluxing toluene gives a mixture of the meso (R,S)-isomer and the corresponding racemate (R,R)+(S,S), which is easily separated by HPLC on a Chiracel OD column to obtain the target meso (R,S)-isomer.
| 【1】 Vigorita, M.G.; et al.; Synthesis and antiinflammatory, analgesic activity of 3,-3'-(1,2-ethanediyl)-bis[2-aryl-4-thiazolidinone] chiral compounds, Part 10. Bioorg Med Chem Lett 2001, 11, 21, 2791. |
| 【2】 Gabriella, M.; et al.; 3,3'-Bi(1,3-thiazolidin-4-one) system. VIII. 3,3'-(1,2-ethanedyl) derivatives ans corresponding 1,1'-disulfones: Synthesis, stereochemistry and antiinflammatory activity. Farmaco 1997, 52, 1, 43. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 54420 | (2S)-2-(3,4-dichlorophenyl)-3-{2-[(2S)-2-(3,4-dichlorophenyl)-4-oxo-1,3-thiazolidin-3-yl]ethyl}-1,3-thiazolidin-4-one | C20H16Cl4N2O2S2 | 详情 | 详情 | ||
| (I) | 54419 | N-[(Z)-(3,4-dichlorophenyl)methylidene]-N-(2-{[(Z)-(3,4-dichlorophenyl)methylidene]amino}ethyl)amine; N~1~,N~2~-bis[(Z)-(3,4-dichlorophenyl)methylidene]-1,2-ethanediamine | C16H12Cl4N2 | 详情 | 详情 | |
| (II) | 18524 | 2-sulfanylacetic acid | 68-11-1 | C2H4O2S | 详情 | 详情 |
Extended Information