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【结 构 式】

【分子编号】54419

【品名】N-[(Z)-(3,4-dichlorophenyl)methylidene]-N-(2-{[(Z)-(3,4-dichlorophenyl)methylidene]amino}ethyl)amine; N~1~,N~2~-bis[(Z)-(3,4-dichlorophenyl)methylidene]-1,2-ethanediamine

【CA登记号】

【 分 子 式 】C16H12Cl4N2

【 分 子 量 】374.09556

【元素组成】C 51.37% H 3.23% Cl 37.91% N 7.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The cyclocondensation of N,N'-bis(3,4-dichlorobenzylidene)ethylenediamine (I) with 2-sulfanylacetic acid (II) in refluxing toluene gives a mixture of the meso (R,S)-isomer and the corresponding racemate (R,R)+(S,S), which is easily separated by HPLC on a Chiracel OD column to obtain the target meso (R,S)-isomer.

1 Vigorita, M.G.; et al.; Synthesis and antiinflammatory, analgesic activity of 3,-3'-(1,2-ethanediyl)-bis[2-aryl-4-thiazolidinone] chiral compounds, Part 10. Bioorg Med Chem Lett 2001, 11, 21, 2791.
2 Gabriella, M.; et al.; 3,3'-Bi(1,3-thiazolidin-4-one) system. VIII. 3,3'-(1,2-ethanedyl) derivatives ans corresponding 1,1'-disulfones: Synthesis, stereochemistry and antiinflammatory activity. Farmaco 1997, 52, 1, 43.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
54420 (2S)-2-(3,4-dichlorophenyl)-3-{2-[(2S)-2-(3,4-dichlorophenyl)-4-oxo-1,3-thiazolidin-3-yl]ethyl}-1,3-thiazolidin-4-one C20H16Cl4N2O2S2 详情 详情
(I) 54419 N-[(Z)-(3,4-dichlorophenyl)methylidene]-N-(2-{[(Z)-(3,4-dichlorophenyl)methylidene]amino}ethyl)amine; N~1~,N~2~-bis[(Z)-(3,4-dichlorophenyl)methylidene]-1,2-ethanediamine C16H12Cl4N2 详情 详情
(II) 18524 2-sulfanylacetic acid 68-11-1 C2H4O2S 详情 详情
Extended Information