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【结 构 式】 
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【分子编号】53975 【品名】2-[6-(dimethylamino)-3-pyridinyl]-3-[(Z)hydrazono]butanenitrile 【CA登记号】n/a |
【 分 子 式 】C11H15N5 【 分 子 量 】217.2738 【元素组成】C 60.81% H 6.96% N 32.23% |
合成路线1
该中间体在本合成路线中的序号：(IV)The condensation of 2-[6-(dimethylamino)pyridin-3-yl]acetonitrile (I) with ethyl acetate (II) by means of NaH in THF gives 2-[6-(dimethylamino)pyridin-3-yl]-3-oxobutyronitrile (III), which is treated with hydrazine in refluxing ethanol/water to yield the corresponding hydrazone (IV). The cyclization of (IV) with ethyl acetoacetate (V) in refluxing dioxane affords 3-[6-(dimethylamino)pyridin-3-yl]-2,5-dimethylpyrazolo[2,3-a]pyrimidin-7-ol (VI), which is treated with refluxing POCl3 to provide the expected 7-chloro derivative (VII). Finally, this compound is treated with dipropylamine (VIII) in refluxing acetonitrile to furnish the target dipropylamino derivative.
| 【1】 Chen, C.; Webb, T.R.; McCarthy, J.R.; Moran, T.J.; Wilcoxen, K.M. (Janssen Pharmaceutica NV; Neurocrine Biosciences Inc.); Pyrazolopyrimidines as CRF receptor antagonists. EP 0880523; JP 2000503661; WO 9729109 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 53973 | 2-[6-(dimethylamino)-3-pyridinyl]acetonitrile | n/a | C9H11N3 | 详情 | 详情 |
| (II) | 17491 | ethyl acetate | 141-78-6 | C4H8O2 | 详情 | 详情 |
| (III) | 53974 | 2-[6-(dimethylamino)-3-pyridinyl]-3-oxobutanenitrile | n/a | C11H13N3O | 详情 | 详情 |
| (IV) | 53975 | 2-[6-(dimethylamino)-3-pyridinyl]-3-[(Z)hydrazono]butanenitrile | n/a | C11H15N5 | 详情 | 详情 |
| (V) | 11819 | ethyl acetoacetate; ethyl 3-oxobutanoate；Acetoacetic ester;Ethyl beta-ketobutyrate;ethyl 3-oxobutyrate | 141-97-9 | C6H10O3 | 详情 | 详情 |
| (VI) | 53976 | 3-[6-(dimethylamino)-3-pyridinyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-ol | n/a | C15H17N5O | 详情 | 详情 |
| (VII) | 53977 | N-[5-(7-chloro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-2-pyridinyl]-N,N-dimethylamine; 5-(7-chloro-2,5-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-dimethyl-2-pyridinamine | n/a | C15H16ClN5 | 详情 | 详情 |
| (VIII) | 21856 | N,N-dipropylamine; N-propyl-1-propanamine | 142-84-7 | C6H15N | 详情 | 详情 |