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【结 构 式】 
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【分子编号】53782 【品名】(3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-({3-[(4-aminobutyl)amino]propyl}amino)-17-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-ol 【CA登记号】 |
【 分 子 式 】C34H65N3O2 【 分 子 量 】547.90912 【元素组成】C 74.53% H 11.96% N 7.67% O 5.84% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(CIV)Reductive amination of ketone (CII) with the deprotected spermidine (XL) in the presence of NaBH3CN provided the triamino derivative (CIII). The Boc protecting groups of (CIII) were then removed by acidic treatment to furnish the target precursor (CIV).
| 【1】 Moriarty, R.M.; et al.; Stereoselective synthesis of squalamine dessulfate. Tetrahedron Lett 1995, 36, 29, 5139. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (CII) | 53780 | (5S,7R,8R,9S,10S,13R,14S,17R)-17-[(1R,4R)-4-(acetyloxy)-1,5-dimethylhexyl]-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-7-yl acetate | C31H50O5 | 详情 | 详情 | |
| (CIII) | 53781 | (1R,4R)-4-((3S,5R,7R,8R,9S,10S,13R,14S,17R)-7-(acetyloxy)-3-{[3-((tert-butoxycarbonyl){4-[(tert-butoxycarbonyl)amino]butyl}amino)propyl]amino}-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-isopropylpentyl acetate | C48H85N3O8 | 详情 | 详情 | |
| (CIV) | 53782 | (3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-({3-[(4-aminobutyl)amino]propyl}amino)-17-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-ol | C34H65N3O2 | 详情 | 详情 | |
| (XL) | 53724 | tert-butyl 3-aminopropyl{4-[(tert-butoxycarbonyl)amino]butyl}carbamate | n/a | C17H35N3O4 | 详情 | 详情 |
Extended Information