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【结 构 式】

【分子编号】53734

【品名】 

【CA登记号】n/a

【 分 子 式 】C31H54O5

【 分 子 量 】506.76676

【元素组成】C 73.47% H 10.74% O 15.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(L)

Preparation of the key intermediate (XIII) starting from chenodeoxycholic acid (XLIV) was also reported. Diacetylation of (XLIV), followed by selective hydrolysis of diacetate (XLV), gave the C-3 alcohol (XLVI). This was oxidized to dienone (XLVII) following a previously reported procedure. Reduction of (XLVII) by lithium in liquid ammonia yielded the saturated ketone (XLVIII). Protection of the 7-hydroxyl group of (XLVIII) using methoxymethyl chloride, followed by ketalization of the 3-ketone, afforded (XLIX). Side-chain elongation in (XLIX) as in Scheme 20248401a produced (L), which was then deprotected giving (XIII).

1 Moriarty, R.M.; Guo, L.; Tuladhar, S.M. (Genaera Corp.); Chemical synthesis of squalamine. WO 9419366 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IL) 53733   n/a C28H46O6 详情 详情
(VIII) 53699 (5S,7R,8R,9S,10S,13R,14S,17R)-17-((1R)-4-{[tert-butyl(dimethyl)silyl]oxy}-1,5-dimethylhexyl)-7-hydroxy-10,13-dimethylhexadecahydro-3H-cyclopenta[a]phenanthren-3-one n/a C33H60O3Si 详情 详情
(XLIV) 53728 (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid n/a C24H40O4 详情 详情
(XLV) 53729 (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-bis(acetyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid n/a C28H44O6 详情 详情
(XLVI) 53730 (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-(acetyloxy)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid n/a C26H42O5 详情 详情
(XLVII) 53731 (4R)-4-[(7R,8S,9S,10S,13R,14S,17R)-7-(acetyloxy)-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]pentanoic acid n/a C26H36O5 详情 详情
(XLVIII) 53732 (4R)-4-[(5S,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid n/a C24H38O4 详情 详情
(L) 53734   n/a C31H54O5 详情 详情
Extended Information