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【结 构 式】

【分子编号】53537

【品名】(Z)-3-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}-3-(propylamino)-2-propenenitrile

【CA登记号】n/a

【 分 子 式 】C13H15N3OS

【 分 子 量 】261.34772

【元素组成】C 59.75% H 5.79% N 16.08% O 6.12% S 12.27%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The reaction of propylamine (I) with di(2-pyridyl)thione (DPT) gives the corresponding isothiocyanate (II), which is condensed with cyanamide (III) and 2-bromo-1-(3-pyridyl)ethanone (IV) by means of NaOMe to yield the adduct (V). This compound, without isolation, cyclizes to the target thiazole.

1 Sorensen, A.R.; Engelhardt, S.; Kurtzhals, P.; Urso, B.; Bowler, A.N.; 2,4-Diaminothiazoles: A novel class of glycogen synthase kinase-3 (GSK-3) inhibitors. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P20.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23923 1-propanamine 107-10-8 C3H9N 详情 详情
(II) 53536 Isothiocyanic acid n-propyl ester; n-Propyl isothiocyanate; Propyl isothiocyanate 628-30-8 C4H7NS 详情 详情
(III) 19648 Cyanamide 420-04-2 CH2N2 详情 详情
(IV) 53085 2-bromo-1-(3-pyridinyl)-1-ethanone n/a C7H6BrNO 详情 详情
(V) 53537 (Z)-3-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}-3-(propylamino)-2-propenenitrile n/a C13H15N3OS 详情 详情
Extended Information