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【结 构 式】 
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【分子编号】53536 【品名】Isothiocyanic acid n-propyl ester; n-Propyl isothiocyanate; Propyl isothiocyanate 【CA登记号】628-30-8 |
【 分 子 式 】C4H7NS 【 分 子 量 】101.17232 【元素组成】C 47.49% H 6.97% N 13.84% S 31.69% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The reaction of propylamine (I) with di(2-pyridyl)thione (DPT) gives the corresponding isothiocyanate (II), which is condensed with cyanamide (III) and 2-bromo-1-(3-pyridyl)ethanone (IV) by means of NaOMe to yield the adduct (V). This compound, without isolation, cyclizes to the target thiazole.
| 【1】 Sorensen, A.R.; Engelhardt, S.; Kurtzhals, P.; Urso, B.; Bowler, A.N.; 2,4-Diaminothiazoles: A novel class of glycogen synthase kinase-3 (GSK-3) inhibitors. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P20. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23923 | 1-propanamine | 107-10-8 | C3H9N | 详情 | 详情 |
| (II) | 53536 | Isothiocyanic acid n-propyl ester; n-Propyl isothiocyanate; Propyl isothiocyanate | 628-30-8 | C4H7NS | 详情 | 详情 |
| (III) | 19648 | Cyanamide | 420-04-2 | CH2N2 | 详情 | 详情 |
| (IV) | 53085 | 2-bromo-1-(3-pyridinyl)-1-ethanone | n/a | C7H6BrNO | 详情 | 详情 |
| (V) | 53537 | (Z)-3-{[2-oxo-2-(3-pyridinyl)ethyl]sulfanyl}-3-(propylamino)-2-propenenitrile | n/a | C13H15N3OS | 详情 | 详情 |
Extended Information