N-{(Z)-anilino[(2-cyclopropyl-2-oxoethyl)sulfanyl]methylidene}guanidine -Drug Synthesis Database

【结构式】

【分子编号】53528

【品名】N-{(Z)-anilino[(2-cyclopropyl-2-oxoethyl)sulfanyl]methylidene}guanidine

【CA登记号】n/a

【分子式】C₁₃H₁₆N₄OS

【分子量】276.3624

【元素组成】C 56.5% H 5.84% N 20.27% O 5.79% S 11.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of N1-amidino-N3-phenylthiourea (I) with 2-bromo-1-cyclopropylethanone (II) in ethanol/acetone gives the N1-amidino-S-(2-cyclopropyl-2-oxoethyl)-N3-phenylisothiourea (III), which without isolation is cyclized to the target aminothiazole by means of TEA.

参考文献中间体

合成目标

【1】 Sorensen, A.R.; Engelhardt, S.; Kurtzhals, P.; Urso, B.; Bowler, A.N.; 2,4-Diaminothiazoles: A novel class of glycogen synthase kinase-3 (GSK-3) inhibitors. 11th RSC-SCI Med Chem Symp (Sept 9 2001, Cambridge) 2001, Abst P20.
【2】 Olesen, P.H.; Kurtzhals, P.; Bowler, A.N.; Soerensen, A.R.; Worsaae, H.; Hansen, B.F. (Novo Nordisk A/S); 2,4-Diaminothiazole derivs.. WO 0156567 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	53527	1-Phenyl-3-guanylthiourea	15989-47-6	C₈H₁₀N₄S	详情	详情
(II)	12436	2-Bromo-1-cyclopropyl-1-ethanone	69267-75-0	C₅H₇BrO	详情	详情
(III)	53528	N-{(Z)-anilino[(2-cyclopropyl-2-oxoethyl)sulfanyl]methylidene}guanidine	n/a	C₁₃H₁₆N₄OS	详情	详情

Extended Information