【结 构 式】 |
【分子编号】56523 【品名】S-{2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl} benzenecarbothioate 【CA登记号】 |
【 分 子 式 】C13H11NO5S 【 分 子 量 】293.30008 【元素组成】C 53.24% H 3.78% N 4.78% O 27.27% S 10.93% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VIII)The protected ligand (IV) was also prepared by a related method. The acylation of thioglycolic acid (V) with benzoyl chloride (VI) under Schotten-Baumann conditions afforded S-benzoyl thioglycolic acid (VII). After activation of (VII) as the corresponding succinimidyl ester (VIII) with N-hydroxysuccinimide and DCC, coupling with triglycine (I) furnished compound (IV).
【1】 Grummon, G.; et al.; Synthesis, characterization and crystal structures of technetium(V)-oxo complexes useful in nuclear medicine. 1. Complexes of mercaptoacetylglycylglycylglycine (MAG3) and its methyl ester derivative (MAG3OMe). Inorg Chem 1995, 34, 7, 1764. |
【2】 Brandau, W.; et al.; Technetium-99m labeled renal function and imaging agents. 3. Synthesis of Tc-99m-MAG3 and biodistribution of by-products. Int J Radiat Appl Instrum Part A - Appl Radiat Isotop 1988, 39, 2, 121. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 56518 | 2-({2-[(2-aminoacetyl)amino]acetyl}amino)acetic acid | C6H11N3O4 | 详情 | 详情 | |
(IV) | 56520 | 1,4,7,10-tetraoxo-1-phenyl-2-thia-5,8,11-triazatridecan-13-oic acid | C15H17N3O6S | 详情 | 详情 | |
(V) | 18524 | 2-sulfanylacetic acid | 68-11-1 | C2H4O2S | 详情 | 详情 |
(VI) | 10463 | Benzoyl chloride | 98-88-4 | C7H5ClO | 详情 | 详情 |
(VII) | 56522 | 2-(benzoylsulfanyl)acetic acid | C9H8O3S | 详情 | 详情 | |
(VIII) | 56523 | S-{2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl} benzenecarbothioate | C13H11NO5S | 详情 | 详情 |
Extended Information