2-(benzoylsulfanyl)acetic acid -Drug Synthesis Database

【结构式】

【分子编号】56522

【品名】2-(benzoylsulfanyl)acetic acid

【CA登记号】

【分子式】C₉H₈O₃S

【分子量】196.22672

【元素组成】C 55.09% H 4.11% O 24.46% S 16.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

The protected ligand (IV) was also prepared by a related method. The acylation of thioglycolic acid (V) with benzoyl chloride (VI) under Schotten-Baumann conditions afforded S-benzoyl thioglycolic acid (VII). After activation of (VII) as the corresponding succinimidyl ester (VIII) with N-hydroxysuccinimide and DCC, coupling with triglycine (I) furnished compound (IV).

参考文献中间体

合成目标

【1】 Grummon, G.; et al.; Synthesis, characterization and crystal structures of technetium(V)-oxo complexes useful in nuclear medicine. 1. Complexes of mercaptoacetylglycylglycylglycine (MAG3) and its methyl ester derivative (MAG3OMe). Inorg Chem 1995, 34, 7, 1764.
【2】 Brandau, W.; et al.; Technetium-99m labeled renal function and imaging agents. 3. Synthesis of Tc-99m-MAG3 and biodistribution of by-products. Int J Radiat Appl Instrum Part A - Appl Radiat Isotop 1988, 39, 2, 121.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	56518	2-({2-[(2-aminoacetyl)amino]acetyl}amino)acetic acid		C₆H₁₁N₃O₄	详情	详情
(IV)	56520	1,4,7,10-tetraoxo-1-phenyl-2-thia-5,8,11-triazatridecan-13-oic acid		C₁₅H₁₇N₃O₆S	详情	详情
(V)	18524	2-sulfanylacetic acid	68-11-1	C₂H₄O₂S	详情	详情
(VI)	10463	Benzoyl chloride	98-88-4	C₇H₅ClO	详情	详情
(VII)	56522	2-(benzoylsulfanyl)acetic acid		C₉H₈O₃S	详情	详情
(VIII)	56523	S-{2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2-oxoethyl} benzenecarbothioate		C₁₃H₁₁NO₅S	详情	详情

Extended Information