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【结 构 式】 
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【分子编号】56516 【品名】2-(methoxyimino)-2-{2-[(2-phenylacetyl)amino]-1,3-thiazol-4-yl}acetic acid 【CA登记号】 |
【 分 子 式 】C14H13N3O4S 【 分 子 量 】319.34104 【元素组成】C 52.66% H 4.1% N 13.16% O 20.04% S 10.04% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)Using a different protection strategy, aminoacid (IV) was protected as the N-phenylacetyl derivative (VII) by treatment with acid chloride (VI). Subsequent DCC-mediated coupling with the cephem derivative (III) furnished (VIII). The N-phenylacetyl group was then selectively removed by enzymatic hydrolysis with penicillin G amidase.
| 【1】 Zenoni, M.; Fuganti, C.; A method for the acylation of the 7-amino group of the cephalosporanic ring. EP 0582102 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 56514 | 7-amino-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C14H15N3O5S3 | 详情 | 详情 | |
| (IV) | 24737 | 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid | 65872-41-5 | C6H7N3O3S | 详情 | 详情 |
| (VI) | 25890 | 2-phenylacetyl chloride；Phenylacetyl chloride;Phenacetyl chloride;Benzeneacetyl chloride | 103-80-0 | C8H7ClO | 详情 | 详情 |
| (VII) | 56516 | 2-(methoxyimino)-2-{2-[(2-phenylacetyl)amino]-1,3-thiazol-4-yl}acetic acid | C14H13N3O4S | 详情 | 详情 | |
| (VIII) | 56517 | 3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-7-[(2-(methoxyimino)-2-{2-[(2-phenylacetyl)amino]-1,3-thiazol-4-yl}acetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C28H26N6O8S4 | 详情 | 详情 |
Extended Information