2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl 4-methylbenzenesulfonate -Drug Synthesis Database

【结构式】

【分子编号】56515

【品名】2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl 4-methylbenzenesulfonate

【CA登记号】

【分子式】C₁₃H₁₃N₃O₅S₂

【分子量】355.39544

【元素组成】C 43.94% H 3.69% N 11.82% O 22.51% S 18.05%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

In a further procedure, 2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetic acid (IV) was activated as the mixed anhydride (V) by treatment with tosyl chloride and triethylamine. After protection of the cephem thioether (III) by silylation with either chlorotrimethylsilane or with bis(trimethylsilyl)acetamide, coupling with the mixed anhydride (V) gave rise to the title compound.

参考文献中间体

合成目标

【1】 Wagner, H.; Jaenicke, O.; Worm, M. (Aventis Pharma AG); Process for the preparation of cefodizime. EP 0226093 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	56514	7-amino-3-({[5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid		C₁₄H₁₅N₃O₅S₃	详情	详情
(IV)	24737	2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid	65872-41-5	C₆H₇N₃O₃S	详情	详情
(V)	56515	2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl 4-methylbenzenesulfonate		C₁₃H₁₃N₃O₅S₂	详情	详情

Extended Information