• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】53163

【品名】methyl 3-[[({(2R,3R,4R,5R,6R)-3-(acetylamino)-5-(acetyloxy)-6-[(acetyloxy)methyl]-2-[(diphenoxyphosphoryl)oxy]tetrahydro-2H-pyran-4-yl}oxy)methyl](ethoxy)phosphoryl]-2-methylpropanoate

【CA登记号】n/a

【 分 子 式 】C32H43NO15P2

【 分 子 量 】743.638684

【元素组成】C 51.69% H 5.83% N 1.88% O 32.27% P 8.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XI)

Treatment of (X) with BuLi and diphenyl chlorophosphate led to stereoselective formation of the alpha phosphate ester (XI). The phenyl phosphate ester groups of (XI) were then deprotected by catalytic hydrogenation over PtO2 to afford (XII), isolated as a mixture of two major diastereomers. Coupling of (XII) with uridine monophosphate morpholidate (XIII) led to the uridine diphosphate-containing derivative (XIV). Finally, saponification of the ester groups of (XIV) with aqueous NaOH furnished the title compound.

1 Reck, F.; et al.; Inhibitors of the bacterial cell wall biosynthesis enzyme MurC. Bioorg Med Chem Lett 2001, 11, 11, 1451.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(X) 53162 methyl 3-[[({(3R,4R,5R,6R)-3-(acetylamino)-5-(acetyloxy)-6-[(acetyloxy)methyl]-2-hydroxytetrahydro-2H-pyran-4-yl}oxy)methyl](ethoxy)phosphoryl]-2-methylpropanoate n/a C20H34NO12P 详情 详情
(XI) 53163 methyl 3-[[({(2R,3R,4R,5R,6R)-3-(acetylamino)-5-(acetyloxy)-6-[(acetyloxy)methyl]-2-[(diphenoxyphosphoryl)oxy]tetrahydro-2H-pyran-4-yl}oxy)methyl](ethoxy)phosphoryl]-2-methylpropanoate n/a C32H43NO15P2 详情 详情
(XII) 53164 methyl 3-[({[(2R,3R,4R,5R,6R)-3-(acetylamino)-5-(acetyloxy)-6-[(acetyloxy)methyl]-2-(phosphonooxy)tetrahydro-2H-pyran-4-yl]oxy}methyl)(ethoxy)phosphoryl]-2-methylpropanoate n/a C20H35NO15P2 详情 详情
(XIII) 53165 {(2R,3S,4R,5R)-5-[2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-3,4-dihydroxytetrahydro-2-furanyl}methyl hydrogen 4-morpholinylphosphonate n/a C13H20N3O9P 详情 详情
(XIV) 53166   n/a C29H46N3O23P3 详情 详情
Extended Information