6,7-dichloro-5,8-quinolinedione -Drug Synthesis Database

【结构式】

【分子编号】53106

【品名】6,7-dichloro-5,8-quinolinedione

【CA登记号】n/a

【分子式】C₉H₃Cl₂NO₂

【分子量】228.03376

【元素组成】C 47.4% H 1.33% Cl 31.09% N 6.14% O 14.03%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(I)

The condensation of 6,7-dichloroquinoline-5,8-dione (I) with 4-(2-aminoethyl)morpholine (II) provided a 2:1 mixture of the title 7-amino quinoline and its 6-amino regioisomer (III), which were separated by column chromatography.

参考文献中间体

合成目标

【1】 Cooley, K.A.; Southwick, E.C.; Ducruet, A.P.; Joo, B.; Vogt, A.; Wipf, P.; Aslan, D.C.; Lazo, J.S.; Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem 2001, 44, 24, 4042.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	53106	6,7-dichloro-5,8-quinolinedione	n/a	C₉H₃Cl₂NO₂	详情	详情
(II)	12880	4-(2-Aminoethyl)morpholine; 2-(4-Morpholinyl)ethylamine; 2-(4-Morpholinyl)-1-ethanamine; N-(2-Aminoethyl)morpholine; N-Morpholine ethanamide	2038-03-1	C₆H₁₄N₂O	详情	详情
(III)	53108	7-chloro-6-{[2-(4-morpholinyl)ethyl]amino}-5,8-quinolinedione	n/a	C₁₅H₁₆ClN₃O₃	详情	详情

合成路线2

该中间体在本合成路线中的序号：(I)

The condensation of 6,7-dichloroquinoline-5,8-dione (I) with 4-(2-aminoethyl)morpholine (II) provided a 1:2 mixture of the title 6-amino quinoline and its 7-amino regioisomer (III), which were separated by column chromatography.

参考文献中间体

合成目标

【1】 Cooley, K.A.; Southwick, E.C.; Ducruet, A.P.; Joo, B.; Vogt, A.; Wipf, P.; Aslan, D.C.; Lazo, J.S.; Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem 2001, 44, 24, 4042.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	53106	6,7-dichloro-5,8-quinolinedione	n/a	C₉H₃Cl₂NO₂	详情	详情
(II)	12880	4-(2-Aminoethyl)morpholine; 2-(4-Morpholinyl)ethylamine; 2-(4-Morpholinyl)-1-ethanamine; N-(2-Aminoethyl)morpholine; N-Morpholine ethanamide	2038-03-1	C₆H₁₄N₂O	详情	详情
(III)	53107	6-chloro-7-{[2-(4-morpholinyl)ethyl]amino}-5,8-quinolinedione	n/a	C₁₅H₁₆ClN₃O₃	详情	详情

Extended Information