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【结 构 式】 
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【药物名称】DA-3003-1, NSC-663284 【化学名称】6-Chloro-7-[2-(4-morpholinyl)ethylamino]-5,8-dihydroquinoline-5,8-dione 【CA登记号】 【 分 子 式 】C15H16ClN3O3 【 分 子 量 】321.76607 |
【开发单位】National Cancer Institute (Originator), University of Pittsburgh (Originator) 【药理作用】ONCOLYTIC DRUGS, Cell Division Cycle CDC25 Phosphatase Inhibitors |
合成路线1
The condensation of 6,7-dichloroquinoline-5,8-dione (I) with 4-(2-aminoethyl)morpholine (II) provided a 2:1 mixture of the title 7-amino quinoline and its 6-amino regioisomer (III), which were separated by column chromatography.
| 【1】 Cooley, K.A.; Southwick, E.C.; Ducruet, A.P.; Joo, B.; Vogt, A.; Wipf, P.; Aslan, D.C.; Lazo, J.S.; Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem 2001, 44, 24, 4042. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 53106 | 6,7-dichloro-5,8-quinolinedione | n/a | C9H3Cl2NO2 | 详情 | 详情 |
| (II) | 12880 | 4-(2-Aminoethyl)morpholine; 2-(4-Morpholinyl)ethylamine; 2-(4-Morpholinyl)-1-ethanamine; N-(2-Aminoethyl)morpholine; N-Morpholine ethanamide | 2038-03-1 | C6H14N2O | 详情 | 详情 |
| (III) | 53108 | 7-chloro-6-{[2-(4-morpholinyl)ethyl]amino}-5,8-quinolinedione | n/a | C15H16ClN3O3 | 详情 | 详情 |
Extended Information