|
【结 构 式】 
|
【分子编号】53098 【品名】Azodicarboxylic acid di-tert-butyl ester 【CA登记号】870-50-8 |
【 分 子 式 】C10H18N2O4 【 分 子 量 】230.264 【元素组成】C 52.16% H 7.88% N 12.17% O 27.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXI)The intermediate hydrazine (XXIII) was obtained by two alternative methods. Alkylation of 4-(3-pyridyl)imidazole (II) with the chiral mesylate (XIX), prepared from (R)-1,3-butanediol (XVIII), furnished, after desilylation with tetrabutylammonium fluoride, the imidazolyl butanol (XX). Condensation of alcohol (XX) with di-tert-butyl azodicarboxylate in the presence of PPh3 yielded the hydrazine dicarboxylate (XXII), which was then deprotected to hydrazine (XXIII) under acidic conditions.
| 【1】 Kaneko, T.; McMillen, W.T.; McLaughlin, R.W.; Ripin, D.H.B.; Vanerplas, B.C. (Pfizer Inc.); Synthesis of carbamate ketolide antibiotics. EP 1088828; JP 2001151792 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 17164 | 3-(1H-imidazol-4-yl)pyridine | C8H7N3 | 详情 | 详情 | |
| (XVIII) | 53095 | (R)-(-)-1,3-Butanediol; (R)-(-)-1,3-Butylene glycol; (R)-(-)-1,3-Dihydroxybutane; (R)-1,3-Butanediol | 6290-03-5 | C4H10O2 | 详情 | 详情 |
| (XIX) | 53096 | (1R)-3-{[tert-butyl(dimethyl)silyl]oxy}-1-methylpropyl methanesulfonate | n/a | C11H26O4SSi | 详情 | 详情 |
| (XX) | 53097 | (3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]-1-butanol | n/a | C12H15N3O | 详情 | 详情 |
| (XXI) | 53098 | Azodicarboxylic acid di-tert-butyl ester | 870-50-8 | C10H18N2O4 | 详情 | 详情 |
| (XXII) | 53099 | di(tert-butyl) 1-{(3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl}-1,2-hydrazinedicarboxylate | n/a | C22H33N5O4 | 详情 | 详情 |
| (XXIII) | 53100 | 3-{1-[(1R)-3-hydrazino-1-methylpropyl]-1H-imidazol-4-yl}pyridine | n/a | C12H17N5 | 详情 | 详情 |
Extended Information