(3R)-4-(2-amino-6-iodo-9H-purin-9-yl)-3-[(octadecyloxy)methyl]butyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate -Drug Synthesis Database

【结构式】

【分子编号】52987

【品名】(3R)-4-(2-amino-6-iodo-9H-purin-9-yl)-3-[(octadecyloxy)methyl]butyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate

【CA登记号】n/a

【分子式】C₄₁H₆₅IN₆O₅

【分子量】848.90901

【元素组成】C 58.01% H 7.72% I 14.95% N 9.9% O 9.42%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XLI)

A related strategy required previous conversion of chloropurine (I) to the iodopurine (XL), which was effected by means of HI. Alkylation of purine (XL) with tosylate (XXXVI) provided (XLI), which was hydrolyzed to the guanine (XIII) using NaOAc/HOAc.

参考文献中间体

合成目标

【1】 Synthesis of acyclic nucleoside derivs.. WO 0008025 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11644	6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine	10310-21-1	C₅H₄ClN₅	详情	详情
(XIII)	52965	(2R)-2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoyl)oxy]butyl stearate		C₄₁H₆₄N₆O₇	详情	详情
(XXXVI)	52984	(2S)-4-[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoyl)oxy]-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)butyl stearate	n/a	C₄₃H₆₇NO₉S	详情	详情
(XL)	14386	6-iodo-9H-purin-2-ylamine; 6-iodo-9H-purin-2-amine		C₅H₄IN₅	详情	详情
(XLI)	52987	(3R)-4-(2-amino-6-iodo-9H-purin-9-yl)-3-[(octadecyloxy)methyl]butyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate	n/a	C₄₁H₆₅IN₆O₅	详情	详情

Extended Information