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【结 构 式】 
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【分子编号】52954 【品名】benzyl (1R)-1-[4-(chlorocarbonyl)cyclohexyl]ethylcarbamate 【CA登记号】n/a |
【 分 子 式 】C17H22ClNO3 【 分 子 量 】323.81932 【元素组成】C 63.06% H 6.85% Cl 10.95% N 4.33% O 14.82% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Racemic trans-4-(1-benzyloxycarbonylaminoethyl)cyclohexanecarboxylic acid (I) was resolved using D-(+)-alpha-phenethylamine. The desired (R)-isomer (II) was activated as the corresponding acid chloride (III), which was further coupled with 4-aminopyridine (IV), yielding amide (V). The benzyloxycarbonyl protecting group of (V) was finally removed by treatment with HBr in HOAc.
| 【1】 Muro, T.; Seki, T.; Abe, M.; Inui, J.; Sato, H. (Mitsubishi Pharma Corp.); Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane cpds. and pharmaceutical use thereof. EP 0370498; JP 1990509475; US 4997834; WO 9005723 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 52952 | 4-(1-{[(benzyloxy)carbonyl]amino}ethyl)cyclohexanecarboxylic acid | n/a | C17H23NO4 | 详情 | 详情 |
| (II) | 52953 | 4-((1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)cyclohexanecarboxylic acid | C17H23NO4 | 详情 | 详情 | |
| (III) | 52954 | benzyl (1R)-1-[4-(chlorocarbonyl)cyclohexyl]ethylcarbamate | n/a | C17H22ClNO3 | 详情 | 详情 |
| (IV) | 25661 | 4-pyridinamine; 4-aminopyridine | 5044-74-5 | C5H6N2 | 详情 | 详情 |
| (V) | 52955 | benzyl (1R)-1-{4-[(4-pyridinylamino)carbonyl]cyclohexyl}ethylcarbamate | n/a | C22H27N3O3 | 详情 | 详情 |
Extended Information