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【结 构 式】

【分子编号】52952

【品名】4-(1-{[(benzyloxy)carbonyl]amino}ethyl)cyclohexanecarboxylic acid

【CA登记号】n/a

【 分 子 式 】C17H23NO4

【 分 子 量 】305.37396

【元素组成】C 66.86% H 7.59% N 4.59% O 20.96%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Racemic trans-4-(1-benzyloxycarbonylaminoethyl)cyclohexanecarboxylic acid (I) was resolved using D-(+)-alpha-phenethylamine. The desired (R)-isomer (II) was activated as the corresponding acid chloride (III), which was further coupled with 4-aminopyridine (IV), yielding amide (V). The benzyloxycarbonyl protecting group of (V) was finally removed by treatment with HBr in HOAc.

1 Muro, T.; Seki, T.; Abe, M.; Inui, J.; Sato, H. (Mitsubishi Pharma Corp.); Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane cpds. and pharmaceutical use thereof. EP 0370498; JP 1990509475; US 4997834; WO 9005723 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 52952 4-(1-{[(benzyloxy)carbonyl]amino}ethyl)cyclohexanecarboxylic acid n/a C17H23NO4 详情 详情
(II) 52953 4-((1R)-1-{[(benzyloxy)carbonyl]amino}ethyl)cyclohexanecarboxylic acid C17H23NO4 详情 详情
(III) 52954 benzyl (1R)-1-[4-(chlorocarbonyl)cyclohexyl]ethylcarbamate n/a C17H22ClNO3 详情 详情
(IV) 25661 4-pyridinamine; 4-aminopyridine 5044-74-5 C5H6N2 详情 详情
(V) 52955 benzyl (1R)-1-{4-[(4-pyridinylamino)carbonyl]cyclohexyl}ethylcarbamate n/a C22H27N3O3 详情 详情
Extended Information