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【结 构 式】 
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【分子编号】52869 【品名】3-amino-1-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one 【CA登记号】 |
【 分 子 式 】C15H13FN2O2 【 分 子 量 】272.2789032 【元素组成】C 66.17% H 4.81% F 6.98% N 10.29% O 11.75% |
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of 3-amino-1-(2-fluorophenyl)-6-methoxyindolin-2-one (I) with isoquinolin-3-ylcarbonyl chloride (II) by means of NaHCO3 in chloroform/dichloromethane/water gives the corresponding amide (III), which is condensed with methyl acrylate (IV) by means of K2CO3 in acetone to yield the propionic ester derivative (V). Finally, the ester group of (V) is hydrolyzed with NaOH in ethanol to afford the target propionic acid derivative as a racemic compound.
| 【1】 Yamada, K.; Hikota, M.; Shikano, T.; Nagasaki, M. (Tanabe Seiyaku Co., Ltd.); 2-Oxoindoline deriv.. EP 0731091; US 5807883; WO 9514668 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 52869 | 3-amino-1-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one | C15H13FN2O2 | 详情 | 详情 | |
| (II) | 56739 | 3-isoquinolinecarboxylic acid | 203626-75-9 | C10H7NO2 | 详情 | 详情 |
| (III) | 56742 | N-[1-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]-3-isoquinolinecarboxamide | C25H18FN3O3 | 详情 | 详情 | |
| (IV) | 14156 | methyl acrylate | 96-33-3 | C4H6O2 | 详情 | 详情 |
| (V) | 56743 | methyl 3-{1-(2-fluorophenyl)-3-[(3-isoquinolinylcarbonyl)amino]-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl}propanoate | C29H24FN3O5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)The condensation of 3-amino-1-(2-fluorophenyl)-6-methoxyindolin-2-one (I) with acrylonitrile (II) by means of K2CO3 in DMSO gives the propionitrile derivative (III), which was submitted to optical resolution with (+)-dibenzoyl tartaric acid to yield enantiomer (IV). The condensation of (IV) with isoquinoline-3-carboxylic acid (V) by means of DEC and HOBt in DMF affords the carboxamide (VI), which is treated with HCl in methanol to provide the propionic ester (VII). Finally, this compound is hydrolyzed with NaOH in methanol/water to furnish the target sodium propionate derivative as a pure enantiomer.
| 【1】 Yamada, K.; Hikota, M.; Shikano, T.; Nagasaki, M. (Tanabe Seiyaku Co., Ltd.); 2-Oxoindoline deriv.. EP 0731091; US 5807883; WO 9514668 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 52869 | 3-amino-1-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one | C15H13FN2O2 | 详情 | 详情 | |
| (II) | 10847 | Acrylonitrile | 107-13-1 | C3H3N | 详情 | 详情 |
| (III) | 56737 | 3-[3-amino-1-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propanenitrile | C18H16FN3O2 | 详情 | 详情 | |
| (IV) | 56738 | 3-[(3S)-3-amino-1-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propanenitrile | C18H16FN3O2 | 详情 | 详情 | |
| (V) | 56739 | 3-isoquinolinecarboxylic acid | 203626-75-9 | C10H7NO2 | 详情 | 详情 |
| (VI) | 56740 | N-[(3S)-3-(2-cyanoethyl)-1-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]-3-isoquinolinecarboxamide | C28H21FN4O3 | 详情 | 详情 | |
| (VII) | 56741 | methyl 3-{(3S)-1-(2-fluorophenyl)-3-[(3-isoquinolinylcarbonyl)amino]-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl}propanoate | C29H24FN3O5 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(V)The isatin derivative (III) was prepared by acylation of diarylamine (I) with oxalyl chloride, followed by intramolecular cyclization of the intermediate (II) under Friedel-Crafts reaction conditions. Treatment of (III) with hydroxylamine led to formation of the oxime (IV), which was further reduced to amine (V) by catalytic hydrogenation over Pd/C. After protection of amine (V) as the benzyl carbamate (VI), alkylation with iodomethane in the presence of K2CO3 produced the 3-methyl oxindole (VII). Removal of the N-carbobenzoxy group of (VII) was achieved by catalytic hydrogenation over Pd/C to yield the deprotected amine, which was resolved by means of dibenzoyl-L-tartaric acid. The target (S)-amine (VIII) was finally acylated with beta-carboline-3-carbonyl chloride (IX) to furnish the title amide.
| 【1】 Yamada, K.; Hikota, M.; Yura, T.; Shikano, T.; Nagasaki, M. (Tanabe Seiyaku Co., Ltd.); Beta-carboline derivs. with anticholecystoquinine activity. EP 0572235; JP 1994041126; US 5434148 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 52865 | N-(2-fluorophenyl)-N-(3-methoxyphenyl)amine; 2-fluoro-N-(3-methoxyphenyl)aniline | C13H12FNO | 详情 | 详情 | |
| (II) | 52866 | 2-[2-fluoro(3-methoxyphenyl)anilino]-2-oxoacetyl chloride | C15H11ClFNO3 | 详情 | 详情 | |
| (III) | 52867 | 1-(2-fluorophenyl)-6-methoxy-1H-indole-2,3-dione | C15H10FNO3 | 详情 | 详情 | |
| (IV) | 52868 | 1-(2-fluorophenyl)-6-methoxy-1H-indole-2,3-dione 3-oxime | C15H11FN2O3 | 详情 | 详情 | |
| (V) | 52869 | 3-amino-1-(2-fluorophenyl)-6-methoxy-1,3-dihydro-2H-indol-2-one | C15H13FN2O2 | 详情 | 详情 | |
| (VI) | 52870 | benzyl 1-(2-fluorophenyl)-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-ylcarbamate | C23H19FN2O4 | 详情 | 详情 | |
| (VII) | 52871 | benzyl 1-(2-fluorophenyl)-6-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylcarbamate | C24H21FN2O4 | 详情 | 详情 | |
| (VIII) | 52872 | (3S)-3-amino-1-(2-fluorophenyl)-6-methoxy-3-methyl-1,3-dihydro-2H-indol-2-one | C16H15FN2O2 | 详情 | 详情 | |
| (IX) | 52873 | 9H-beta-carboline-3-carbonyl chloride | C12H7ClN2O | 详情 | 详情 |